PT  - JOURNAL ARTICLE
AU  - Dan, Jennifer M.
AU  - Mateus, Jose
AU  - Kato, Yu
AU  - Hastie, Kathryn M.
AU  - Yu, Esther Dawen
AU  - Faliti, Caterina E.
AU  - Grifoni, Alba
AU  - Ramirez, Sydney I.
AU  - Haupt, Sonya
AU  - Frazier, April
AU  - Nakao, Catherine
AU  - Rayaprolu, Vamseedhar
AU  - Rawlings, Stephen A.
AU  - Peters, Bjoern
AU  - Krammer, Florian
AU  - Simon, Viviana
AU  - Saphire, Erica Ollmann
AU  - Smith, Davey M.
AU  - Weiskopf, Daniela
AU  - Sette, Alessandro
AU  - Crotty, Shane
TI  - Immunological memory to SARS-CoV-2 assessed for up to 8 months after infection
AID  - 10.1126/science.abf4063
DP  - 2021 Jan 06
TA  - Science
PG  - eabf4063
4099  - http://science.sciencemag.org/content/early/2021/01/06/science.abf4063.short
4100  - http://science.sciencemag.org/content/early/2021/01/06/science.abf4063.full
AB  - Understanding immune memory to SARS-CoV-2 is critical for improving diagnostics and vaccines, and for assessing the likely future course of the COVID-19 pandemic. We analyzed multiple compartments of circulating immune memory to SARS-CoV-2 in 254 samples from 188 COVID-19 cases, including 43 samples at ≥ 6 months post-infection. IgG to the Spike protein was relatively stable over 6+ months. Spike-specific memory B cells were more abundant at 6 months than at 1 month post symptom onset. SARS-CoV-2-specific CD4+ T cells and CD8+ T cells declined with a half-life of 3-5 months. By studying antibody, memory B cell, CD4+ T cell, and CD8+ T cell memory to SARS-CoV-2 in an integrated manner, we observed that each component of SARS-CoV-2 immune memory exhibited distinct kinetics.