Table 1

Association results for the independent SNPs in the MHC identified with stepwise regression in the European and African American samples. The odds ratio and frequency is given for the A1 allele, where OR > 1 indicates a protective effect. Odds ratios and P values were computed for univariate and multivariate regression models. C, cytosine; G, guanine; T, thymine; A, adenine.

SNPA1A2Frequency in
controllers
Frequency in
progressors
UnivariateMultivariate
ORP valueORP value
European
rs9264942CT0.5950.3362.92.8 × 10−352.16.3 × 10−16
rs4418214CT0.2400.0754.41.4 × 10−341.84.9 × 10−4
rs2395029GT0.1390.0325.39.7 × 10−262.13.5 × 10−4
rs3131018CA0.7770.6252.14.2 × 10−161.51.2 × 10−5
African American
rs2523608GA0.5220.3262.68.9 × 10−202.33.7 × 10−15
rs2255221TG0.2640.1372.73.5 × 10−141.92.1 × 10−6
rs2523590CT0.3000.1642.41.7 × 10−132.31.2 × 10−12
rs9262632GA0.0970.0343.11.0 × 10−82.22.8 × 10−4