Table 1.

Mutations in melanoma cell lines with accumulated β-catenin. AA, amino acid.

Cell lineNucleotide changeβ-catenin AA change
501 melTCT → TTTS37F
1088 melExons 2, 3*AA 1-87
Exons 2, 3, 4*AA 1-173
1241 melTCT → TTTS37F
1335 melWild typeWild type
624 melTCT → TATS45Y
888 melTCT → TTTS37F
928 melWild typeWild type
1290 melTCT → TTTS37F
  • * Exons deleted from mRNA.

  • † Amino acids deleted. Minimum deletion of amino acid sequence is based on the location of the closest downstream initiator codon.

  • ‡ These cells also lack WT APC protein.