Table 2

Root-mean-square differences (Å) between germline (g) and mature (m) antibody Fabs.

Comparison*VLVHBoth chainsVLVH rotation
AllAllAll
g− to g+0.380.660.510.990.600.944.60°
g− to m−0.460.920.601.050.781.176.89°
g− to m+0.410.780.300.650.771.116.94°
g+ to m−0.410.840.661.150.601.053.63°
g+ to m+0.400.790.651.020.590.953.51°
m− to m+0.300.650.450.840.380.750.44°
  • * g−, germline without hapten; g+, germline with hapten; m−, 48G7 without hapten; m+, 48G7 with hapten.