Table 4

Distinct prion strains generated in humans with inherited prion diseases and transmitted to Tg mice [data from (24,110)].

Inoculum Host species Host PrP genotypeIncubation time PrPSc (kD)
Days (± SEM) n/n0
NoneHuman FFI(D178N, M129)19
FFI Mouse Tg(MHu2M) 206  ±  7 7/7  19
FFI → Tg(MHu2M) Mouse Tg(MHu2M)136  ±  1  6/6  19
None Human fCJD(E200K)21
fCJD Mouse Tg(MHu2M) 170  ±  210/10 21
fCJD → Tg(MHu2M) Mouse Tg(MHu2M)167  ±  3 15/15 21