Table 1

Results of targeted disruptions of mouse STAT genes.

Targeted gene Phenotype Refer- ence
Stat1No innate response to viral or bacterial infection(31, 32)
Stat2 Early embryonic lethal (29)
Stat3 Early embryonic lethal; no gastrulation (38)
Stat4 No TH1 cell function (34, 35)
Stat5ANo breast development or lactation (41)
Stat5BNo breast development or lactation (42)
Stat6No TH2 cell function(37-39)