Table 1

Immunoreactivities in the human frontal and temporal cortices and hippocampus for βAPP and Ubi-B, for which the mRNA is expressed in the +1 reading frame (resulting in βAPP+1and Ubi-B+1 protein). Tissues were obtained from controls and neuropathologically confirmed AD and DS cases (12). Immunoreactivity present in tangles, dystrophic neurites, and neuritic plaques of patients is expressed as a percentage of the total number of patients studied.

DiseaseFrontal cortex (area 11) Temporal cortex (area 38) Hippocampus
βAPP+1Ubi-B+1βAPP+1Ubi-B+1βAPP+1Ubi-B+1
Nondemented controls* (n = 12)0 0 0  8 050
AD (n = 21) 1980 43 95 50 95
DS (n = 7) 8686 86 86 71 86
  • * Young (n = 6) and elderly (n = 6) nondemented controls. Controls were matched for sex, age, and postmortem delay.

  • In elderly, nondemented patients with age-related neuropathology (tangles and plaques).

  • Early- (<65 years, n = 10) and late- (>65 years, n = 11) onset AD.