Table 2

Relative risk (RR) of prostate cancer according to quartiles of IGF-I, IGF-II, and IGFBP-3.

Charac- teristic RR associated with quartiles
1 2 34 Trend*P-value
Univariate analysis
IGF-I 1.00 1.32 (0.62 to 2.80) 1.81 (0.92 to 3.56) 2.41 (1.23 to 4.74) 0.006
IGF-II 1.00 1.00 (0.54 to 1.84) 0.67 (0.33 to 1.37) 0.97 (0.48 to 1.95) 0.74
IGFBP-3 1.00 0.92 (0.48 to 1.79) 0.69 (0.33 to 1.44) 1.07 (0.54 to 2.11) 0.96
Multivariate analysis (simultaneous adjustment for IGF-I or IGFBP-3)
IGF-I 1.00 1.94 (0.83 to 4.56) 2.83 (1.27 to 6.28)4.32 (1.76 to 10.6) 0.001
IGFBP-3 1.00 0.50 (0.23 to 1.10) 0.33 (0.14 to 0.82) 0.41 (0.17 to 1.03)0.09
  • * Test for linear trend calculated by assigning the medians of the quartiles as scores.

  • n = 151 for cases, one case missing measure of IGF-I.

  • Ninety-five percent confidence intervals.