Table 1

Titers of ICs and antibodies to dsDNA for γ+/– and γ–/– mice. Results are expressed as a percent of a pooled serum from 7-month-old B/W female mice used to create a standard curve (48). Means ± SEM of two separate experiments of 21 heterozygous and 29 homozygous deficient female animals 6 to 7 months of age are shown.

Mouse strain
γ+/–γ–/–C57Bl/6 γ–/–
Immune
complexes* 84  ±  3066  ±  18<1
Anti-dsDNA
Total IgG109  ±  2498  ±  12<1
IgG1 92  ±  21165  ±  271
IgG2a77  ±  16106  ±  14<1
IgG2b101  ±  4086  ±  16<1
IgG3121  ±  24 146  ±  231
IgM143  ±  19114  ±  11<1
  • * Aggregated IgG was used as a positive control for C1q binding.