Table 2

Evidence for the presence of linkage with human obesity phenotypes.*

Gene or markerChromosomal locationN pairsPhenotypeInferential statisticsReferences
D1S202 1q31-32large pedigreeBMIP= 4.7 × 10−5Murrayet al. (1994)
ACP1 2p25>300BMIP = .004Bailey-Wilson et al. (1993)
GRL 5q31-q3288BMI > 27P = .009Clement et al. (1996)
BF 6p21.3>168skinfolds.01 <P < 0.03Wilson et al. (1991)
TNFA, Tnfir24, D6S273,2916p21.2>255% body fat.002 <P < .048Norman et al. (1995)
GLO1 6p21.2>168skinfolds, relative weight.004 < P < 0.05Wilson et al. (1991)
SUR(D11S419)11p15.167BMI > 27P = .0032Hani et al. (1997)
D1S200 1p32-p22137 sibshipsBMIP = .009Chagnon et al. (1997)
ADA to MC3R20p12 to 20q13.3258% body fat; BMI, fasting insulin.008 >P > .0005Lembertas et al. (1997)
D2S1788 2p21pedigreesserum leptinLOD = 4.95; P ∼ 1.8 × 106 Comuzzie et al. (1997)
LEP regionchromosome 7>1000BMIP < 2 × 10−5Allison and Heo (1998) (meta-analysis of 5 studies)
KEL 7q33402BMI, skinfoldsP < .0001Borecki et al. (1994)
ESD 13q14.1-q14.2194% body fat, skinfoldsP < 0.04Borecki et al. (1994)
ADA 20q12-q13.11428BMI, skinfolds.02 <P < .001Borecki et al. (1994)
P1 22q11.2-qter>168relative weightP = .03Wilson et al. (1991)
D3S2432 3p24.2-p22874% body fatLOD = 2.0Norman et al. (1997)
D11S2000,236611q21-q22874% body fatLOD = 3.1Normanet al. (1997)
MC5R 18p11.2242-289BMI, Σ 6 skinfolds, fat mass, % body fat0.001 < P < 0.02Chagnon et al. (1997)
ADA, MC3R,D20S17,12020q12-q13258BMI, Σ 6 skinfolds, fat mass, % body fat0.004 < P < 0.02Lembertas et al. (1997)
  • * Adapted from a table compiled by Y. C. Chagnon, L. Pérusse, and C. Bouchard. Reprinted with permission fromObes. Res. 6, 76 (1998).

  • Detailed reference information is in (29). Most results were obtained with the single point sib-pair method. Abbreviations: ACP1, acid phosphatase; SUR, sulfonylurea receptor; MCR, melanocortin receptor; GRL, glucocorticoid receptor; BF, properdin factor B; TNFir24, dinucleotide repeat marker locus near the tumor necrosis factor α gene; GLO1, glyoxylase I; LEP, leptin; KEL, Kell blood group; ESD, esterase D; ADA, adenosine deaminase; P1, P blood group; BMI, body mass index.