Table 1

Candidate signaling molecules involved in energy homeostasis in the CNS.

CatabolicAnabolic
CRH* NPY*
α-MSH* AGRP*
CCKMCH
Bombesinorexins A and B (= hypocretins 1 and 2)
Somatostatingalanin
Thyrotropin-releasing hormoneβ-endorphin
Calcitonin-gene– related peptidedynorphin
Neurotensinnorepinephrine
Glucagon-like peptide–1growth hormone– releasing hormone
Serotonin
  • * These molecules are particularly important in the regulation of adiposity.