Table 1

Nonhuman primate models for testing HIV-1 vaccines.

Species and virus Limitations
Chimpanzees
HIV-1Scarcity of animals, expense, limited viral replication and absence of disease when infected with patient isolates
Macaques
SIV Differences from HIV-1 in viral sequences and important envelope epitopes
SHIV Different from HIV-1–induced human disease in kinetics of CD4+ cell loss