Table 1

Reduced ability of raclopride to induce catalepsy in DARPP-32 mutant mice. Catalepsy testing (39) was conducted 30 min after intraperitoneal injection of vehicle or raclopride (n = 12 per dose group). Wild-type and mutant control mice injected with vehicle remained stationary for an average of 17 s. Data represent percentage increase in catalepsy (mean ± SEM) relative to vehicle-injected control animals. Data were analyzed by ANOVA, followed by Student's t test.

Raclopride (mg/kg)Increase in catalepsy (%)
Wild typeMutant
0.25236.5 ± 48.735.0 ± 31.5**
0.5369.5 ± 62.265.7 ± 33.5**
1.0579.2 ± 65.2387.9 ± 43.3*
2.0865.6 ± 49.2806.1 ± 48.7
  • * P < 0.05 compared with wild-type control;

  • ** P < 0.01 compared with wild-type control.