Table 1

Effect of inhibition of IDO activity on rejection of allogeneic concepti (10).

Mating genotype (♀ × ♂) Gestation stage (dpc)Mean no. concepti per ♀ (no. ♀ treated)Appearance of concepti
InhibitorPlaceboInhibitorPlacebo
CBA × CBA6.5–8.57.3 (3) 7.5 (2) NormalNormal
9.5–15.56.7 (7)6.5 (6)NormalNormal
CBA × B66.57.3 (3)8.5 (2)NormalNormal
7.5–8.55.5* (10)8.3 (6)Majority inflamedNormal
9.5–15.50.2** (19)5.4 (9)AbsentNormal
  • * P < 0.01 or

  • ** P < 0.0001 by analysis of variance compared to placebo controls at each time point.