Effect of maternal lymphocytes and one MHC class I alloantigen on embryo rejection (10).
Mating genotype (♀ × ♂) | IDO inhibitor | No. ♀ examined (dpc) | Mean no. concepti per ♀ |
---|---|---|---|
CBA (RAG-1 –/–) × B6 | Yes | 5 (11.5) | 7.8 |
CBA (RAG-1 –/–) × B6 | Yes | 2 (at term) | 7 (pups/litter) |
BM3* → CBA (RAG-1 –/–) × B6 | Yes | 4 (12.5–14.5) | 0 |
CBA × GK† | Yes | 4 (11.5) | 0 |
CBA × GK† | No | 21 (at term) | 6.4 (pups/litter) |