Table 2

Effect of maternal lymphocytes and one MHC class I alloantigen on embryo rejection (10).

Mating genotype (♀ × ♂)IDO inhibitorNo. ♀ examined (dpc)Mean no. concepti per ♀
CBA (RAG-1 –/–) × B6Yes5 (11.5)7.8
CBA (RAG-1 –/–) × B6Yes2 (at term)7 (pups/litter)
BM3* → CBA (RAG-1 –/–) × B6Yes4 (12.5–14.5)0
CBA × GK Yes4 (11.5)0
CBA × GK No21 (at term)6.4 (pups/litter)
  • * CD8+ T cells in BM3 TCR transgenic mice recognize H-2Kb (14).

  • GK mice are H-2Kb transgenic mice made on the CBA background (3).