Table 1

VEGFR-3 genotypes and corresponding phenotypes. Data are the number of embryos or mice with the indicated genotype from VEGFR-3+/− breeding pairs. After E9, all the VEGFR-3−/− embryos were growth retarded; they were necrotic after E12.5. Edema of the pericardial sac was observed at E10 in 82% (9 out of 11) of the null embryos. ND, not determined.

AgeVEGFR-3+/+VEGFR-3+/−VEGFR-3−/−ND Total
E9.0 to E9.5 315119 13 114
E10.019 24* 11 1 55
E12 to E13 9 19 3 6 37
E14 4  6  2 4 16
Adults 53 83  0 0 136
  • * A single E10 VEGFR-3+/− embryo had edema of the pericardium.

  • Necrotic.