Table 1 Survival analysis of the effect of homozygosity at the three *HLA* class I loci -*A*, -*B*, and -*C* on susceptibility to progression to three AIDS endpoints (AIDS-1993, AIDS-1987, and death) for seroconverters of MACS, MHCS, SFCC, and ALIVE (20–22). HLA class I typing is described in (40). Homozygosity at one locus only and homozygosity at two or three loci were considered as covariables in a Cox model analysis (only five individuals were homozygous at *HLA-A*, -*B*, and -*C* loci, precluding a robust statistical treatment of triple homozygotes). Relative hazards (RH) and their*P* values are given for AIDS-1993, AIDS-1987, and death. There were not a sufficient number of African Americans homozygous for two or three *HLA* class I loci to provide a robust analysis. Homozygosity at each of the loci (*HLA-A*, -*B*, and -*C*) was considered as a Cox model explanatory variable. Each analysis was performed on seroconverters in combined cohorts, separately for Caucasians and African Americans, and for all ethnicities. Analyses were performed without considering specific allele protection and also as adjusted for the AIDS accelerating effects of *B*35* and *Cw*04*(41). RH values were similar, and adjusted values are presented here. A survival analysis was also performed after adjusting the RH values for the protective effects of *CCR5-Δ32*,*CCR2-64I*, and *SDF1-3'A* (22). The results (27) revealed no epistatic interaction of these loci with *HLA* homozygosity because the adjusted RH and*P* values were largely consistent with those reported here. Dashes indicate no data available.