Table 2

Caucasian seroconverters were analyzed for MACS, MHCS, and SFCC cohorts and the combination of all cohorts. The alleles B*35 and Cw*04 are each considered as codominant allele variables in a Cox proportional hazards model, that is, the allele variable has a value of 0, 1, or 2 corresponding to the number of copies of the allele carried by the individual. The analysis for B*35/+ and B*35/B*35 considers the effect ofB*35 without taking into account the presence or absence ofCw*04; likewise, the analysis of Cw*04 ignores the effect of B*35. Because these two alleles are in strong, positive linkage disequilibrium in Caucasians (24) (that is, on most chromosomes where one of these alleles is present the other is present also), an additional analysis was made for individuals carrying one of these alleles but not both. The three pairs of columns on the right give the results of analyses in which heterozygosity for B*35but not Cw*04, for Cw*04 but not B*35, and for B*35 and Cw*04 together were considered as explanatory variables in a Cox model. Homozygotes for either or both of these alleles were excluded from this analysis (39). The results of a survival analysis in which the RH was adjusted by considering the protective genotypes of CCR5,CCR2, and SDF1 (15) as additional covariants were virtually identical to the unadjusted RH andP values presented here (27). Failure to observe significant association for either HLA-B*35 orHLA-Cw*04 for MHCS and SFCC may reflect small sample size or a biased depletion of very rapid progressors to AIDS in both of these cohorts (20, 32), diminishing ability to observe HLA B*35 and Cw*04 influence on rapid progression. Dashes indicate no data available.

AIDS outcome and cohortN/eventB*35/+ andB*35/B*35 Cw*04/+ andCw*04/Cw*04B*35, no Cw*04genotypes Cw*04, no B*35genotypesCw*04 and B*35genotypes
RH PRH PRHPRH PRHP
AIDS-1993:
Combined 329/252 1.839 x 10−5 1.822 x 10−5 1.890.28 1.84 0.04 1.790.001
MACS 195/173 1.690.003 1.57 0.005 16.0 3 x 10−4 1.77 0.07 1.82 0.008
MHCS 58/34 1.280.60 1.67 0.26 0.0 0.99 2.29 0.43 1.540.37
SFCC 68/43 1.36 0.52 0.89 0.844.51 0.170.000.99 1.01 0.99
AIDS-1987:
Combined 330/208 2.35 3 x 10−7 2.29 3 x 10−8 2.73 0.09 2.410.004 2.28 2 x 10−5
MACS 196/1512.57 1 x 10−6 2.183 x 10−6 14.5 4 x 10−4 2.41 0.01 2.93 1 x 10−5
MHCS58/30 1.60 0.33 2.25 0.08 0.00 0.997.25 0.08 1.95 0.17
SFCC 68/26 2.060.22 1.35 0.65 16.3 0.03 0.00 0.99 1.580.49
Death:
Combined 330/1672.202 x 10−5 2.10 5 x 10−6 1.64 0.50 1.93 0.06 2.01 0.001
MACS196/124 2.761 x 10−6 2.122 x 10−5 12.3 0.001 2.28 0.022.93 6 x 10−5
MHCS 58/24 0.920.87 0.98 0.97 0.00 0.99 0.00 1.00 0.990.99
SFCC 68/18 0.81 0.78 0.95 0.950.00 0.99 0.92 0.91