Table 1

Fasting glucose, triglyceride, and insulin levels of male wild-type, heterozygote, and PT-1B−/− littermates fed a normal or high-fat diet. Values are given as the means ± SEM. Statistical analysis was done with a two-tailed, unpaired, Student'st test. ND, not determined.

DietPTP-1B+/+PTP-1B+/−PTP-1B−/−
NormalHigh fatNormalHigh fatNormalHigh fat
Glucose (mM)6.1  ±  0.38.1  ±  0.6* 6.2  ±  0.37.3  ±  0.66.3  ±  0.37.0  ±  0.4
Triglycerides (mM)1.84  ±  0.762.41  ±  0.191.43  ±  0.442.44  ±  0.320.86  ±  0.18* 1.46  ±  0.15*
Insulin (ng/ml)0.30  ±  0.020.98  ±  0.32ND0.97  ±  0.300.33  ±  0.080.45  ±  0.14*
  • * P < 0.05 (n = 6 to 10).