Table 1

Genetic information about distribution of deletions in virulent M. bovis and BCG strains. Parentheses afterM. bovis indicate how many strains of virulent M. bovis were missing the genetic element. Start and end position are based on the 162 segments of genome available athttp://www.ncbi.nih.gov/Entrez/nucleotide.html. A list of the 129 deleted ORFs may be accessed athttp://molepi.stanford.edu/bcg.

Deletion regionStrains where missingNumber of ORFsORFs deletedStart (segment: bp)End (segment: bp)
RD1* All BCG strains9Rv3871–Rv3879c160: 7,534160: 16,989
RD2* BCG-Danish, BCG-Prague, BCG-Glaxo, BCG-Frappier, BCG-Connaught, BCG-Phipps, BCG-Tice, BCG-Pasteur11Rv 1978–Rv198888: 14,21189: 8,598
RD3* M. bovis (3/8)14Rv1573–Rv1586c70: 7,67770: 16,923
RD4M. bovis (8/8)3Rv0221–Rv0223c12: 17,43212: 19,335
RD5M. bovis(8/8)5Rv3117–Rv3121135: 27,437135: 30,212
RD6* M. bovis (8/8)11Rv1506c–Rv1516c65: 23,61465: 36,437
RD7M. bovis (8/8)8Rv2346c–Rv2353c103: 17,622103: 26,584
RD8BCG-Frappier, BCG-Connaught4Rv0309–Rv031216: 17,01816: 20,446
RD9M. bovis (8/8)7Rv3617–Rv3623153: 21,131154: 2,832
RD10M. bovis(8/8)3Rv1255c–Rv1257c55: 3,68955: 6,696
RD11M. bovis(8/8)5Rv3425–Rv3429145: 30,303146: 1,475
RD12M. bovis (8/8)4Rv2072c–Rv2075c93: 9,30193: 11,331
RD13M. bovis(4/8)16Rv2645–Rv2660c118: 12,475118: 23,455
RD14BCG-Pasteur8Rv1766–Rv1773c79: 30,57379: 39,642
RD15M. bovis (8/8)15Rv1963c–Rv197788: 1,15388: 13,873
RD16BCG-Moreau6Rv3400–Rv3405c145: 5,012145: 12,621
  • * RD1, RD2, and RD3 were detected by Mahairas et al. (14) and RD6 was described by Brosch et al. (15). RD3 and RD13 are prophages phiRv1 and phiRv2, respectively.