Table 1

Tissues with viral RNA+. Cells after intravaginal inoculation of SIV. NT, not tested; −, not detected; +, ≥6 × 10−3 vRNA+ cells per square millimeter of tissue (>2 copies per cell); ++, ≥4.5 × 10−1 vRNA+ cells per square millimeter of tissue; ++++, ≥3.5 vRNA+ cells per square millimeter of tissue.

TissueDay 1Day 3Day 7Day 12
Vagina++++
Cervix+++++++
Draining LN* ++++
Distal LN ++++
Other LT ++++
Bone marrow++
Central nervous system§ NTNT
  • * Common, external and internal iliacs and inguinal LN.

  • Mesenteric, lumbar, and axillary LN.

  • Thymus, tonsil, spleen, gut-associated LT in ileum.

  • § Frontal cortex, thalamus, basal ganglia, III, IV ventricles.