Table 4

Expansion of two infected populations of T cells after sexual mucosal transmission of SIV. Cells that met criteria for infection defined in Table 1 that were stained or not stained immunohistochemically by antibodies for the indicated markers were first detectable 3 days after intravaginal inoculation after extensive search of 20 sections of endocervix with an area of 1660 mm2. For comparison, infected cell counts at later times were normalized to this area. Semilogarithmic plots of the frequency of vRNA+ cells that are HLA-DR+ or HLA-DR and Ki67+ or Ki67versus days of infection are linear; thus, both populations are expanding exponentially.

MarkersEndocervixLN
Day 3Day 7Day 12Day 12
HLA-DR+1416519964,623
13729405214,102
Ki67+22629902,825
267436858 18,675