Table 3

Numbers of lymphoid cells inPI3Kγ −/− mice. Thymi (n = 12), spleens (n = 5), and all lymph nodes (n= 5) from 4- to 7-week-old PI3Kγ +/− andPI3Kγ −/− littermate mice or 6-week-oldPI3Kγ +/− chimeric andPI3Kγ −/− chimeric mice (n = 4 for all organs) were analyzed. Bold numbers indicate statistically significant differences between PI3Kγ +/− andPI3Kγ −/− mice or betweenPI3Kγ +/−rag1 −/−and PI3Kγ −/−rag1 −/− chimeric mice (Mann-WhitneyU test; P < 0.05). Values are given as the mean ± SEM.

Lymphatic organPI3Kγ+/− PI3Kγ−/− PI3Kγ+/− → rag1−/−PI3Kγ−/− → rag1−/−
Thymus (×108)2.04  ±  0.271.18  ± 0.101.53  ±  0.400.52  ± 0.20
Spleen (×107)3.94  ±  0.683.70  ±  0.742.42  ±  0.712.25  ±  0.39
Lymph nodes (×107)2.68  ±  0.502.70  ±  0.523.02  ±  0.873.15  ±  0.95