Table 1

Spectra of compensated mutants isolated after evolution in LB and in mice.

ResistanceResistance mutation*Growth condition during compensationCompensatory mutationNumber of independently evolved mutations examined
ExtragenicIntragenicReversion
Fusidic acidP413LLB 026 (see Table 2)228
P413LMice 011 (see Table 2)1425
StreptomycinK42NLB14 (seeTable 3) 0014
K42NMice 010 (seeTable 3)010
  • * Amino acid changes (11).

  • The type and number of compensatory mutations or revertants found. The significance of the difference in compensatory mutations found was determined by Fisher's exact test (18). For both resistances,P values were <10−4.