Table 1

Putative pathogenicity genes in N. meningitidis strain MC58, listed by functional category. Systematic gene names start with NMB (N. meningitidisserogroup B), followed by a number indicating the gene position with regard to the origin of replication.

Previously known genes New genes indentified in strain MC58
Acquisition
NMB0460Transferrin-binding protein 2 (tbp2) NMB0293TonB-dependent receptor, putative
NMB0461 Transferrin-binding protein 1 (tbp1)NMB0718 Ferrochelatase (hemH)
NMB0632 Iron(III) ABC transporter, ATP-binding protein (fbpB) NMB0750Bacterioferritin comigratory protein (bcp)
NMB0633Iron(III) ABC transporter, permease protein NMB1346TonB-dependent receptor, putative, authentic frame shift
NMB0634 Iron(III) ABC transporter, periplasmic binding protein (fbpA) NMB1449 TonB-dependent receptor, authentic point mutation
NMB1206 Bacterioferritin B (bfrB) NMB1829TonB-dependent receptor
NMB1207 Bacterioferritin A (bfrA)NMB1882 TonB-dependent receptor
NMB1540Lactoferrin-binding protein A (lbpA) NMB1990Iron(III) ABC transporter, permease protein
NMB1541 Lactoferrin-binding protein B (lbpB) NMB1991 Iron(III) ABC transporter, permease protein
NMB1668 Hemoglobin receptor (hmbR)NMB2132Transferrin-binding protein-related protein
NMB1880ABC transporter, periplasmic solute-binding protein, putative
NMB1989 Iron(III) ABC transporter, periplasmic binding protein
Colonization
NMB0018 Pilin PilE NMB00143-Deoxy-d-manno-octulosonic-acid transferase (kdtA)
NMB0019 pilS cassette NMB0181 Outer membrane protein OmpH, putative
NMB0020 pilS cassette NMB0547 Type IV pilin protein
NMB0021 pilS cassette NMB0586Adhesin, putative
NMB0022 pilS cassette NMB0992 Adhesin (hsf)
NMB0023 pilS cassette NMB0995 Macrophage infectivity potentiator-related protein
NMB0024 pilS cassette NMB1483Lipoprotein NlpD, putative
NMB0025 Large pilS cassetteNMB1567 Macrophage infectivity potentiator
NMB0026 pilS cassette NMB1946 Outer membrane lipoprotein
NMB0049pilC2 protein, authentic frame shift NMB1961 VacJ-related protein
NMB0051 Twitching motility protein NMB1994Adhesin/invasin, putative
NMB0052 Twitching motility protein PilT
NMB0182 Outer membrane protein Omp85
NMB0329Type IV pilus assembly protein (pilF)
NMB0332 Type IV prepilin peptidase (pilD)
NMB0333 Pilus assembly protein PilG
NMB0382 Outer membrane protein class 4 (rmpM)
NMB0442Opacity protein, authentic frame shift
NMB0922α-2,3-Sialyltransferase
NMB0926 Opacity protein
NMB1053 Class 5 outer membrane protein (opc)
NMB1429Outer membrane protein PorA
NMB1465 Opacity protein, authentic frame shift
NMB1527 ADP-heptose–LPS heptosyltransferase II (rfaF)
NMB1636 Opacity protein, authentic frame shift
NMB1704 β-1,4-glucosyltransferase (lgtF)
NMB1705 α-1,2-N-acetylglucosamine transferase (rfaK)
NMB1926 Lacto-N-neotetraose biosynthesis glycosyl transferase LgtE
NMB1928Lacto-N-neotetraose biosynthesis glycosyl transferase LgtB
NMB1929 Lacto-N-neotetraose biosynthesis glycosyl transferase LgtA
NMB1985 Adhesion and penetration protein (hap)
NMB2032 Lipopolysaccharide glycosyl transferase, authentic frame shift (lgtG)
NMB2039 Major outer membrane protein PIB (porB)
NMB2156 Heptosyltransferase I (rfaC)
Evasion
NMB0067 Polysialic acid capsule biosynthesis protein SiaD, truncation NMB0393Multidrug resistance protein
NMB0068 Polysialic acid capsule biosynthesis protein SiaC NMB2127 Protease, putative
NMB0069Polysialic acid capsule biosynthesis protein SiaB
NMB0070Polysialic acid capsule biosynthesis protein synX
NMB0071Capsule polysaccharide export outer membrane protein CtrA
NMB0072Capsule polysaccharide export inner-membrane protein CtrB
NMB0073Capsule polysaccharide export inner-membrane protein CtrC
NMB0074 Capsule polysaccharide export ATP-binding protein CtrD
NMB0082 Capsule polysaccharide modification protein LipA
NMB0083 Capsule polysaccharide modification protein LipB
NMB0216 Catalase (kat)
NMB0700 IgA-specific serine endopeptidase
NMB1332Carboxy-terminal peptidase (prc)
NMB1398 Cu-Zn-superoxide dismutase (sodC)
NMB1714 Multidrug efflux pump channel protein MtrE
NMB1715 Multiple transferable resistance system protein MtrD
Toxins
NMB0017UDP-3-O-hydroxymyristoyl N-acetylglucosamine deacetylase (envA) NMB0178Acyl-(acyl-carrier-protein)–UDP–N-acetylglucosamineO-acetyltransferase (lpxA)
NMB0199Lipid-A-disaccharide synthase (lpxB) NMB0179(3R)-Hydroxymyristoyl-(acyl carrier protein) dehydratase (fabZ)
NMB0493 Hemagglutinin/hemolysin-related proteinNMB0180 UDP-3-O-(3- hydroxymyristoyl)-glucosamineN- acetyltransferase (lpxD)
NMB0496 Hemolysin activator-related protein NMB1210 Toxin-activating protein, putative
NMB0585 Iron-regulated protein FrpA, putativeNMB1646 Hemolysin, putative
NMB1214Hemagglutinin/hemolysin-related protein NMB1762 Hemolysin activation protein HecB, putative
NMB1407 FrpA-related protein, degenerate NMB1763 Toxin-activating protein, putative
NMB1415 Iron-regulated protein FrpC
NMB1768Hemagglutinin/hemolysin-related protein
NMB1779Hemagglutinin/hemolysin-related protein
NMB1780 Hemolysin activation protein HecB, putative
Unknown
NMB1753 VapD-related protein