Table 1

The rate of appearance of dividing CD8+ T cells is increased by IL-15 and reduced by IL-2. The experiments were performed as described in Fig. 3, (22), and the text. Cells analyzed were alive, CFSE+, and CD8+. The percentages of recovered, transferred T cells that had divided during the course of the experiments in mice receiving control antibody ranged from 11.6 to 37.3%. The percentage of control proliferation of transferred cells in experimental mice was calculated as the percentage of the surviving, transferred T cells that divided in mice treated with the indicated antibodies divided by the percentage of the surviving, transferred T cells that divided in mice treated with control antibody.

Donor age (months)% of control proliferation of transferred cells in mice treated with
Anti–IL-2Anti–IL-2 + Anti–IL-2RαAnti–IL-2RβAnti–IL-7 + Anti–IL-7Rα
 3458
 3469
 6337
10189
10187
12354505.251.759.5
47.4
12476.936.867.5
18177.525.593.4