Table 2

Evidence that BMP-2 plus BMP-4 can substitute for FCS in allowing neuronal development. Purified P6 OPCs were cultured in PDGF for 5 days, in PDGF and either FCS or BMPs for another 3 days, and then in serum-free medium with bFGF alone for 7 days.

Markers15% FCS (%)BMP2 + BMP4 (%)
A2B528 ± 521 ± 2
GC00
GFAP1 ± 0.61 ± 0.9
MAP272 ± 473 ± 2
NF-M24 ± 314 ± 6
NF-L21 ± 612 ± 4