Table 1

A20−/− mice succumb to sublethal doses of LPS and TNF. Indicated doses of LPS or TNF were given to 17- to 20-day-old A20+/+ and A20−/− littermates. Numbers of mice surviving at 2 hours are indicated over the numbers of mice injected. Surviving mice were observed for 6 hours further to rule out delayed effects of LPS or TNF.

GenotypeLPS (mg/kg)TNF (mg/kg)
512.5250.10.20.4
+/+, +/−4/44/44/45/52/22/2
−/− 0/40/4