Table 1

Susceptibility of mice lacking Bax, Bak, or both to anti-Fas injection. Mice were injected intravenously with 0.5 μg of monoclonal antibody to Fas (Jo2, Pharmingen) per gram of body weight and killed when moribund or observed for up to 24 hours. Mean survival time in hours ± 1 SD is shown for mice that died.

Genotype Dead/injected Mean survival (hours)
Bak −/− 9/13 5.2  ±  1.7
Bak+/− or +/+9/146.0  ±  2.7
Bax −/− 7/103.8  ±  1.2
Bax+/− or+/+13/13 2.6  ±  1.9
Bax−/−, Bak−/−0/3 (killed after 9 hours)