Table 2

Cholesterol and sphingolipid binding proteins and their putative functions. SP-A/B, surfactant proteins A and B; HE1, human epididymis; PDGFR, platelet-derived growth factor receptor; PG, phosphatidylglycerol; ER, endoplasmic reticulum.

ProteinLipidFunctionRef.
CaveolinCholesterol, fatty acidsLipid transport, caveolae internalization(71,72)
PromininCholesterolStructure of microvilli(73)
ApoBPhospholipidsAssembles LDL lipids in ER(74)
Lipocalins and calycinsMultipleBind lipid ligands(75)
Proteolipids, LipophilinsMultipleMyelinogenesis, secretory proteins(76)
SynaptophysinCholesterolSynaptic vesicle traffic(77)
SP-A/BPG, PCAssembles surfactant lipids(78,79)
HE1CholesterolLipid transport from lysosomes(80,81)
NAP22CholesterolOrganizes cholesterol in synthetic membranes and regulates neurite outgrowth(82, 83)
PDGFR Cholesterol SphingolipidSignal transduction(84)
Mal/BENE/PlasmolipinGalactolipidsBinds multiple membrane lipids(85)
HemolysinCholesterol SphingolipidsBacterial toxin(86)
MARCKSPSSignal transduction(53)
PrionCholesterol SphingolipidsUnknown(48)
β-Amyloid peptideSphingolipidsUnknown(87)
HIV-1 gp120SphingolipidsViral attachment to membrane(87)