Table 1

Components of the Mec1p/Tel1p (ATR/ATM) signaling network in different organisms.

ProteinOrganism
Budding yeastFission yeastHumans
PIKKMec1pRad3ATR
Tel1pTel1ATM
PIKK subunitLcd1p/Ddc2p/Pie1pRad26ATRIP/hRAD26
RFC-likeRad24pRad17hRAD17
PCNA-likeRad17pRad1hRAD1
Ddc1pRad9hRAD9
Mec3pHus1hHUS1
Adaptor?Rad9pCrb2?
Transducer kinaseRad53p Cds1hCHK2/hCDS1
Chk1p Chk1hCHK1