Table 2

Chromosome breakage analysis of FA and control cell lines was performed as in (7). Groups of experiments for lymphoblasts are separated by a line space. I and II indicate experiment number for fibroblast cell lines. S, MMC-sensitive; R, MMC-resistant; L, EBV-transformed lymphoblasts; F, SV-40 transformed fibroblasts; ND, not determined; wt, wild type.

Cell line MMC (ng/ml)% Cells with radialsPhenotype
III
Lymphoblasts
PD7L (wt)208R
EUFA121L (FA-F)2045S
HSC62L (FA-D1)2038S
EUFA423L (FA-D1)2091S
HSC230L (FA-B)2094S
PD7L (wt)202R
EUFA121L (FA-F)2064S
EUFA423L (FA-D1)2090S
EUFA424L208R
EUFA425L200R
EUFA664L204R
EUFA665L206R
EUFA666L20ND
Fibroblasts
GM0637F (wt)25106R
GM6914F (FA-A)256449S
EUFA423F (FA-D1) + pcDNA3-empty258891S
EUFA423F (FA-D1) + pcDNA3-HA-BRCA2252428R
EUFA423F + human chromosome 1325915R