* Has additional four-node motif: (X→Z, W; Y→Z, W; Z→W),

*N*_{real}= 150,*N*_{rand}= 85 ± 15,*Z*= 4.† Has additional four-node motif: (X→Y, Z; Y→Z; Z→W),

*N*_{real}= 204,*N*_{rand}= 80 ± 20,*Z*= 6. The three-node pattern (X→Y, Z; Y→Z; Z→Y) also occurs significantly more than at random. It is not a motif by the present definition because it does not appear with completely distinct sets of nodes more than*U*= 4 times.‡ Has additional four-node motif: (X→Y; Y→Z, W; Z→X; W→X),

*N*_{real}= 914,*N*_{rand}= 500 ± 70,*Z*= 6.§ Has two additional three-node motifs: (X→Y, Z; Y→Z; Z→Y),

*N*_{real}= 3e5,*N*_{rand}= 1.4e3 ± 6e1,*Z*= 6000, and (X→Y, Z; Y→Z),*N*_{real}= 5e5,*N*_{rand}= 9e4 ± 1.5e3,*Z*= 250.