Table 1

Effects of drug treatments on nonmuscle myosin II, anillin, and the microtubule midzone in the presence of (±)-blebbistatin as described for Fig. 3. ER, endoplasmic reticulum.

TargetDrugMechanismMyosinAnillinMidzone
TubulinNocodazoleDepolymerizationDelocalizedDelocalizedAbsent
TaxolStabilizationNo effectNo effectRobust
ActinLatrunculinDepolymerizationDelocalizedDelocalizedDisorganized
KinasesStaurosporineGeneral inhibitionDelocalizedNo effectDisrupted
Aurora-IAurora kinaseDelocalizedNo effectDisrupted
Y27632Rho-kinaseDelocalizedNo effectNo effect
OlomoucineCDKNo effectNo effectNo effect
AlsterpaulloneCDKNo effectNo effectNo effect
RoscovitineCDKNo effectNo effectNo effect
ProteolysisMG132ProteasomeProlongedProlongedProlonged
KinesinsMonastrolEg5 inhibitionNo effectNo effectNo effect
SecretionBrefeldinER-Golgi transportNo effectNo effectNo effect