Molecular markers of HESCs.

Listed are 13 molecular markers for identifying undifferentiated pluripotent HESCs. These markers are expressed (enriched) in undifferentiated HESCs and are turned off after differentiation. There are two groups: class I, cloned markers that are well defined and unambiguous, and class II, cell surface antigens detected by antibodies but requiring more extensive characterization.

Class IClass II
GenBankUnigeneGene
NM_002701Hs.2860Oct-3/4(7,8,10,12)SSEA-3(7,12)
NM_003212Hs.75561TDGF1 (Cripto) [unpublished]SSEA-4(7,8,10,12)
L07335Hs.816Sox2(12)TRA-1-60(7,8,10,12)
NM_003240Hs.25195LeftyA [unpublished]TRA-1-81(7,10,12)
AL558479Hs.125359Thy-1 cell surface antigen(12)TRA-2-54(12)
BF510715Hs.1755FGF4(12)GCTM-2(8)
NM_009556Hs.335787Rex1 (ZFP-42)(12)