Table 1

DNA damage checkpoint and innate immune genes under positive selection in the bat lineages. The rate ratio ω of dN/dS was calculated using multiprotein alignments of P. alecto and M. davidii sequences with orthologous sequences from human, rhesus macaque, mouse, rat, dog, cattle, and horse. ω0 is the average ratio in all branches, ω1 is the average ratio in nonbat branches, and ω2 is the ratio in the bat branch. A low P value indicates that the ω2 model fits the data better than the ω1 model.

LineageSymbolGeneω0
(average)
ω1
(other)
ω2
(target)
P value
AncestorTLR7Toll-like receptor 70.28210.26702.77783.54E-07
ATMAtaxia telangiectasia mutated0.200960.195950.71631.34E-05
MDM2Mdm2 p53 binding protein homolog (mouse)0.133580.126150.810854.05E-04
NLRP3NLR family, pyrin domain–containing 30.17880.17141.18841.93E-04
MAP3K7Mitogen-activated protein kinase kinase kinase 70.02160.01940.47868.93E-03
RAD50RAD50 homolog0.096570.093430.288827.95E-03
PRKDCProtein kinase, DNA-activated, catalytic polypeptide0.230360.227680.451556.80E-03
KU80X-ray repair complementing defective repair in Chinese hamster cells 50.311450.304360.917473.75E-02
c-RELv-rel reticuloendotheliosis viral oncogene homolog (avian)0.24950.24031.57171.11E-02
P. alectoTBK1TANK-binding kinase 10.06430.05220.29301.29E-09
LIG4Ligase IV, DNA, ATP-dependent0.120330.113760.247978.91E-04
IL18Interleukin 18 (interferon-γ–inducing factor)0.52980.45321.76472.66E-04
IFNGInterferon-γ0.50100.45271.32824.89E-03
ISG15ISG15 ubiquitin-like modifier0.20690.19090.43872.63E-02
DDX58DEAD (Asp-Glu-Ala-Asp) box polypeptide 580.30400.29230.46611.23E-02
M. davidiiIFNAR1Interferon (α, β, and ω) receptor 10.49540.472331.09247.00E-03
TP53Tumor protein p530.256230.239330.481237.00E-03
BRCA2Breast cancer 2, early onset0.490020.477320.642131.31E-03
IRAK4Interleukin-1 receptor–associated kinase 40.16700.15830.35311.96E-02