Table 1 Binding of GL and mature (Mat) antibodies to gp120 and eOD variants.

Values represent KDs in nM measured by surface plasmon resonance (SPR). Detectable binding to GL antibodies is in boldface.

AntigenAntibody
VRC0112A123BNC60NIH45-46PGV04PGV19PGV20VRC-CH31
GLMatGLMatGLMatGLMatGLMatGLMatGLMatGLMat
Wild-typeCore.HXB2>1055>1056>10536>10535>10548>10520>10519>10547
eOD-Base N276D>1055>105380>1054100>10514>105110>105310017,00016>10530,000
Germline-targetedCore.BaL-GT118000.53200116,4004>1050.6>10517025145,500435,0001800
eOD-GT144,0001>1052300>10583>1053>105478001000110010>105>105
eOD-GT6442200040014,000200410452,0001019883628,00029,000