Table 1 Fast signaling properties of PV+ interneurons.
PropertyFunctional consequenceMolecular mechanismReference(s)
Fast EPSCsFast EPSP time course;
coincidence detection
GluA1 and GluA4 AMPA
receptor subunits
(23, 37)
Fast IPSCsHigh-frequency
network oscillations
GABRA1 GABAA
receptor subunits
(129, 130)
Dendritic K+ channels
(high activation threshold,
fast deactivation)
Sublinear summation;
sensitivity to distributed
inputs
Kv3 (27, 28)
Perisomatic K+ channels
(high activation threshold,
fast deactivation)
Short action potentials;
fast-spiking AP phenotype
Kv3 (7, 131)
D-type K+ channels in axon
initial segment
Coincidence detection;
delayed spiking during
long current pulses
Kv1 (50, 53, 54)
Supercritical Na+ channel
density in axon
Fast axonal action potential
propagation; fast-spiking
AP phenotype
NaV1.1
NaV1.6
(43, 49, 50)
Fast presynaptic Ca2+ channelsSpeed and temporal
precision of GABA release
Cav2.1, P/Q-type
Ca2+ channel
(5760)
Tight coupling between
presynaptic Ca2+ channels
and release sensors
Speed and temporal precision
of synaptic transmission
Unknown (57, 59)
Fast release sensorsSpeed and temporal precision
of synaptic transmission
Synaptotagmin 2 (63, 64, 66, 67)