Table 2

List of putatively advantageous genes identified by the intersection of functional and selection candidate gene lists. An en dash (–) indicates nonsignificant P values (see tables S11 and S12 for all values). All gene descriptions are based on RefSeq (23) unless otherwise noted.

Gene identified in 200-kb regionXP-EHHXP-EHH empirical
uncorrected P value
iHS iHS empirical uncorrected P value
EPAS1
Endothelial PAS domain protein 1
0.820.002
CYP2E1
Cytochrome P450, family 2, subfamily E, polypeptide 1
0.710.007
EDNRA
Endothelin receptor type A
0.70.008
ANGPTL4
Angiopoietin-like 4
0.690.008
CAMK2D
Calcium/calmodulin-dependent protein kinase II delta
0.680.009
EGLN1
Egl nine homolog 1
0.96†, 0.86†*0.0002†, 0.001†*2.68*0.01*
HMOX2
Heme oxygenase (decycling) 2
30.001
CYP17A1
Cytochrome P450, family 17, subfamily A, polypeptide 1
40.007
PPARA
Peroxisome proliferator-activated receptor alpha
3.580.009
PTEN
Phosphatase and tensin homolog
3.90.007

*EGLN1 was significant for both iHS and XP-EHH analyses.

EGLN1 spanned two genomic regions for XP-EHH.