Spontaneous and GC-dependent mutation rates. Relative changes from the corresponding WT rate are in parentheses. *, P < 0.05 (t-test) versus the corresponding WT rate; **, P < 0.01; ***, P < 0.001; ±, SEM; n/a, not applicable.
| Genotype | Spontaneous mutation rate (×10−8) | MAT-switching mutation rate (×10−5) | Relative change in rate from spontaneous |
| WT | 5.8 ± 2.3 (1) | 1.4 ± 0.5 (1) | 240 |
| WT G1/S | n/a | 8.1 ± 1.0 (5.9)*** | 1400 |
| mlh1Δ | 239 ± 46 (41)*** | 5.6 ± 1.4 (4)** | 23 |
| msh6Δ | 229 ± 42 (39)*** | 2.3 ± 0.35 (1.6) | 10 |
| rev3Δ | 8.1 ± 2.4 (1.4) | 1.6 ± 0.31(1.1) | 200 |
| rev3Δ/rad30Δ | 10.1 ± 2.3 (1.7) | 3.2 ± 0.66 (2.3)** | 310 |
| pol32Δ | 20 ± 7.5 (3)* | 0.66 ± 0.5 (0.5) | 33 |
| pol30(K127,164R) | 4.6 ± 0.02 (1) | 2.9 ± 0.3 (2.1) | 630 |
| pol2-4 | 43 ± 11 (7)** | 6.0 ± 0.78 (4.3)** | 140 |
| pol3-01 | 440 ± 35 (76)** | 3.1 ± 1.0 (2.2) | 7 |
| dun1Δ | 15 ± 6 (3) | 2.0 ± 0.6 (1.5) | 130 |