Table 1

Spontaneous and GC-dependent mutation rates. Relative changes from the corresponding WT rate are in parentheses. *, P < 0.05 (t-test) versus the corresponding WT rate; **, P < 0.01; ***, P < 0.001; ±, SEM; n/a, not applicable.

GenotypeSpontaneous mutation
rate (×10−8)
MAT-switching
mutation rate (×10−5)
Relative change in rate
from spontaneous
WT5.8 ± 2.3 (1)1.4 ± 0.5 (1)240
WT G1/Sn/a8.1 ± 1.0 (5.9)***1400
mlh1Δ239 ± 46 (41)***5.6 ± 1.4 (4)**23
msh6Δ229 ± 42 (39)***2.3 ± 0.35 (1.6)10
rev3Δ8.1 ± 2.4 (1.4)1.6 ± 0.31(1.1)200
rev3Δ/rad30Δ10.1 ± 2.3 (1.7)3.2 ± 0.66 (2.3)**310
pol32Δ20 ± 7.5 (3)*0.66 ± 0.5 (0.5)33
pol30(K127,164R)4.6 ± 0.02 (1)2.9 ± 0.3 (2.1)630
pol2-443 ± 11 (7)**6.0 ± 0.78 (4.3)**140
pol3-01440 ± 35 (76)**3.1 ± 1.0 (2.2)7
dun1Δ15 ± 6 (3)2.0 ± 0.6 (1.5)130