Table 1

Correction of hematologic parameters and urine concentration defect in SCD mice by inactivation of BCL11A. All animals were analyzed at 8 to 10 weeks after birth. Data are means ± SEM. P values were calculated by two-tailed t test between the SCD and SCD/Bcl11a–/– animals; *P < 0.002, **P < 1 × 10−5. N = 17, 14, and 5 for the control, SCD, and SCD/Bcl11a–/– animals, respectively. RBC, red blood cell; Hb, hemoglobin; Hct, hematocrit; MCV, mean corpuscular volume; MCH, mean corpuscular hemoglobin content; MCHC, mean corpuscular hemoglobin concentration; Retic, reticulocytes; RDW, red cell distribution width.

MiceRBC
(×106/μl)
Hb
(g/dl)
Hct
(%)
MCV
(fl)
MCH
(pg)
MCHC
(g/dl)
Retic
(%)
RDW
(%)
Urine concentration
(mOsm)
Control10.1 ± 0.213.1 ± 0.344.2 ± 1.044.1 ± 1.413.0 ± 0.429.7 ± 0.63.1 ± 0.619.0 ± 0.72440 ± 213
SCD6.4 ± 0.57.8 ± 0.628.3 ± 1.944.8 ± 1.612.3 ± 0.627.5 ± 0.638.2 ± 3.926.9 ± 0.51037 ± 82
SCD/Bcl11a–/–9.8 ± 0.4*13.6 ± 0.7**46.2 ± 1.4**47.2 ± 0.913.8 ± 0.229.3 ± 0.87.0 ± 0.3*23.4 ± 0.4*2133 ± 333*