Table 1.

Summary of somatic mutations. UTR, untranslated region. ND, not determined because synonymous mutations were not evaluated in the RefSeq genes analyzed in (5).

Coding changesNoncoding changesTotal mutations
Tumor typeScreenGene setMutated genesMissenseNonsenseInsertionDeletionDuplicationSynonymousSplice site or UTR
Colorectal cancers Discovery This study 325 237 14 0 8 0 93 12 364
All RefSeq 848 722 48 4 27 18 ND 30 942
Validation This study 88 81 9 1 2 2 30 6 131
All RefSeq 183 197 34 4 14 5 ND 15 299
Breast cancers Discovery This study 460 304 26 2 28 1 131 14 506
All RefSeq 1137 909 64 5 78 3 ND 53 1243
Validation This study 62 52 3 0 3 0 19 2 79
All RefSeq 167 153 11 2 15 2 ND 7 209