Table 1.

Association of rs560887 with FPG levels in normoglycemic individuals from a GWA study and replication analyses. Association was tested in the additive model, adjusted for age, sex, and BMI. All individuals were normoglycemic (FPG < 6.1 mmol/l). Per A allele effect size was estimated from the regression coefficient β. Overall meta-analysis includes replication populations (DESIR NG, NFBC86, and obese children). DESIR controls are nonobese NG individuals.

Mean fasting glucose (mmol/l) by rs560887 genotype
FPG N MAF GG GA AA Variance (%) Per-A allele effect size (mmol/l) [95% CI]           P          
DESIR controls (stage 1) 654 0.33 5.15 ± 0.33 5.06 ± 0.37 4.93 ± 0.34 3.90 -0.10 [-0.14; -0.06] 4 × 10-7
DESIR NG (stage 2) 3419 0.30 5.26 ± 0.45 5.19 ± 0.46 5.14 ± 0.47 0.74 -0.06 [-0.08; -0.04] 3 × 10-8
DESIR cohort (stage 1 and stage 2) 4073 0.30 5.24 ± 0.44 5.17 ± 0.45 5.10 ± 0.46 1.05 -0.07 [-0.09; -0.05] 1 × 10-12
NFBC86 5073 0.30 5.18 ± 0.40 5.10 ± 0.42 5.05 ± 0.40 1.10 -0.07 [-0.08; -0.05] 6 × 10-16
Obese children 861 0.28 4.94 ± 0.43 4.88 ± 0.43 4.80 ± 0.47 1.09 -0.07 [-0.11; -0.02] 4 × 10-3
Overall meta-analysis 9353 0.30 5.18 ± 0.43 5.11 ± 0.44 5.06 ± 0.44 0.91 -0.06 [-0.08; -0.05] 4 × 10-23