Table 1.

Relationship between dose level and antitumor activity of BiTE antibody blinatumomab in relapsed NHL patients. Abbreviations used are FL, follicular lymphoma; MCL, mantle cell lymphoma; CLL, chronic lymphocytic leukaemia. For details of trial design, see (25).

Blinatumomab dose levels tested (mg/m2 per day)PatientsTumor regression (percent)Complete regression (disease)Partial regression (disease)
0.0005, 0.0015, 0.005 12 0 (0) 0 0
0.015, 0.030 19 4 (21) 2 (MCL, FL) 2 (FL, CLL)
0.060 7 7 (100) 2 (MCL, FL) 5 (MCL, 4 FL)