Table 1.

Summary of somatic mutations in four tumor types. Pancreas data have their basis in 24 tumors analyzed in the current study; brain data have their basis in 21 nonhypermutable tumors analyzed in (15); and colorectal and breast data have their basis in 11 breast and 11 colorectal tumors analyzed in (14). Nonsilent numbers in parentheses refer to percentage of total nonsynonymous mutations, and substitutions numbers in parentheses refer to percentage of total substitutions. The total number of substitutions includes synonymous as well as nonsilent mutations identified in the indicated study.

PancreasBrainColorectalBreast
Number of mutated genes 1007 685 769 1026
Number of nonsilent mutations 1163 748 849 1112
Missense 974 (83.7) 622 (83.2) 722 (85) 909 (81.7)
Nonsense 60 (5.2) 43 (5.7) 48 (5.7) 64 (5.8)
Insertion 4 (0.3) 3 (0.4) 4 (0.5) 5 (0.4)
Deletion 43 (3.7) 46 (6.1) 27 (3.2) 78 (7.0)
Duplication 31 (2.7) 7 (0.9) 18 (2.1) 3 (0.3)
Splice site or UTR 51 (4.4) 27 (3.6) 30 (3.5) 53 (4.8)
Total number of substitutions 1484 937 893 1157
Substitutions at C:G base pairs
C:G to T:A 798 (53.8) 601 (64.1) 534 (59.8) 422 (36.5)
C:G to G:C 142 (9.6) 67 (7.2) 61 (6.8) 325 (28.1)
C:G to A:T 246 (16.6) 114 (12.1) 130 (14.6) 175 (15.1)
Substitutions at T:A base pairs
T:A to C:G 142 (9.6) 87 (9.3) 69 (7.7) 102 (8.8)
T:A to G:C 79 (5.3) 24 (2.6) 59 (6.6) 57 (4.9)
T:A to A:T 77 (5.2) 44 (4.7) 40 (4.5) 76 (6.6)
Substitutions at specific dinucleotides
5′-CpG-3′ 563 (37.9) 404 (43.1) 427 (47.8) 195 (16.9)
5′-TpC-3′ 218 (14.7) 102 (10.9) 99 (11.1) 395 (34.1)