Table 3.

Mutations of the TP53, PI3K, and RB1 pathways in GBM samples. Mut, mutated; Amp, amplified; Del, deleted; Alt, altered.

TP53 pathwayPI3K pathwayRB1 pathway
Tumor sampleTP53MDM2MDM4All genesPTENPIK3CAPIK3R1IRS1All genesRB1CDK4CDKN2AAll genes
Br02X Del Alt Mut Alt Del Alt
Br03X Mut Alt Mut Alt
Br04X Mut Alt Mut Alt Mut Alt
Br05X Amp Alt Mut Alt Del Alt
Br06X Del Alt
Br07X Mut Alt Mut Alt Del Alt
Br08X Del Alt
Br09P Mut Alt Amp Alt
Br10P Mut Alt
Br11P Mut Alt
Br12P Mut Alt Mut Alt
Br13X Mut Alt Del Alt
Br14X Mut Alt Del Alt
Br15X Mut Del Alt
Br16X Amp Alt Amp Alt
Br17X Mut Alt Del Alt
Br20P
Br23X Mut Alt Del Alt
Br25X Mut Alt Del Alt
Br26X Mut Alt Del Alt
Br27P Mut Alt Amp Alt
Br29P Mut Alt
Fraction of tumors with altered gene/pathway* 0.55 0.05 0.05 0.64 0.27 0.09 0.09 0.05 0.50 0.14 0.14 0.45 0.68
  • * Fraction of affected tumors in 22 Discovery Screen samples.