Table 1

Lethality of WT and airborne-transmissible A/H5N1 virus in ferrets upon inoculation via different routes. n, number of animals; N.A., not applicable.

Inoculation routeVirusDead or moribund
(no. dead/no. tested)
Day of death postinoculation
(no.)
IntratrachealA/H5N1wildtype
A/H5N1/F5
6/6*
6/6
2 (n = 2), 3 (n = 4)
3 (n = 6)
IntranasalA/H5N1wildtype/P10
A/H5N1HA Q222L,G224S PB2 E627K/P10
A/H5N1/F2
A/H5N1/F5
2/2†
0/4
0/2
1/2
6 (n = 2)
N.A.
N.A.
6 (n = 1)
AirborneA/H5N1wildtype
A/H5N1HA Q222L,G224S PB2 E627K/P10
A/H5N1/F2
A/H5N1/F5
N.A.
0/3
0/2
0/1
N.A.
N.A.
N.A.
N.A.

*These data refer to a published study (45).

†These ferrets were inoculated with P10 H5N1wildtype virus, but data are consistent with previous studies that used larger groups of animals inoculated with the original strain (39, 40).