Table 1

In vivo efficacy data in the P. berghei rodent malaria model. “Activity”: average parasitemia reduction; “Survival”: average life span after infection (6 to 7 days for untreated mice); “Cure”: no parasite present at day 30.

Compound1 × 10 mg/kg oral1 × 30 mg/kg oral1 × 100 mg/kg oral
Activity (%)Survival (%)Activity (%)Survival (days)Cure (%)Activity (%)Survival (days)Cure (%)
NITD609*99.613.399.624.15099.2>30100
Artesunate707.3897.2976.7
Artemether816.2976.9997.6
Chloroquine99.6899.78.7>99.912
Mefloquine9515.29818.28928

*Methylcellulose 0.5%/0.1% Solutol HS15 formulation (n = 10 mice).

Tween 80 7%/3% ethanol formulation (n ≥ 10 mice).