Table 1

MIC of BTZ043 against three different mycobacterial species and their resistant mutants.

Strain MIC
(ng/ml)
Codon Amino acid
M. smegmatis mc21554TGCCysteine
M. smegmatis MN474000GGCGlycine
M. smegmatis MN84>16,000TCCSerine
M. bovis BCG 2TGCCysteine
M. bovis BCG BN2>16,000TCCSerine
M. tuberculosis H37Rv1TGCCysteine
M. tuberculosis NTB9250GGCGlycine
M. tuberculosis NTB110,000TCCSerine