Table 1

Acetylation regulates diverse protein classes and biological categories. Acetylated proteins were grouped into major cellular functional categories or into protein classes on the basis of their known functions or function predicted by functional domains.

Cellular functional categories and protein classesNumber of acetylated proteinsNumber of acetylation sites
DNA replication5298
DNA damage and repair72167
Chromatin remodeling2646
Cell cycle132243
RNA transcription3171
RNA splicing109206
Nuclear hormone signaling922
Nuclear transport1741
Cytoskeleton reorganization50137
Nucleotide exchange factors5592
Endocytosis and vesicular trafficking3962
DNA/RNA helicases46105
Ubiquitin ligases and deubiquitylases4670
Protein kinases4771
Acetyltransferases and deacetylases2161
Methyltransferases and demethylases1234
Transcription factors2940
Adaptor proteins1440
Ribosomal proteins75136